At the new Buddh International Circuit, the 24-year-old German led every lap of the race after starting from pole position. He also set the fastest lap right at the finish.
Britain’s Jenson Button, the 2009 world champion, unite his grasp on second place overall by finishing 8.4 seconds behind the German, whereas Ferrari’s Fernando Alonso took 3rd place a further 15.8 seconds adrift.
The champion celebrated on the podium by drinking champagne from the gleaming silver trophy after being joined in celebration by Red Bull technical head Adrian Newey although struck a more solemn mood afterwards.
Vettel now has 374 points with two races remaining, McLaren’s Button 240, Alonso 227 and Red Bull’s Australian Mark Webber, who finished 4th after starting on the front row-221.